Search Results for: epigenetics

Epigenetics

Epigenetics PDF
Author: C. David Allis
Publisher: CSHL Press
Size: 29.29 MB
Format: PDF, Docs
Category : Medical
Languages : en
Pages : 502
View: 1908

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Epigenetics Book Description

by C. David Allis, Epigenetics Books available in PDF, EPUB, Mobi Format. Download Epigenetics books, The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms in which it has been most studied. Thus, there are chapters on histone and DNA methylation, siRNAs and gene silencing; X-chromosome inactivation, dosage compensation and imprinting; and discussion of epigenetics in microbes, plants, insects, and mammals. The last part of the book looks at how epigenetic mechanisms act in cell division and differentiation, and how errors in these pathways contribute to cancer and other human diseases. Also discussed are consequences of epigenetics in attempts to clone animals. This book is a major resource for those working in the field, as well as being a suitable text for advanced undergraduate and graduate courses on gene regulation.


Epigenetics Protocols

Epigenetics Protocols PDF
Author: Trygve O. Tollefsbol
Publisher: Springer Science & Business Media
Size: 14.46 MB
Format: PDF
Category : Science
Languages : en
Pages : 302
View: 1232

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Epigenetics Protocols Book Description

by Trygve O. Tollefsbol, Epigenetics Protocols Books available in PDF, EPUB, Mobi Format. Download Epigenetics Protocols books, Recent advances in epigenetic research as well as the development of exciting new technologies have helped greatly in unraveling the many mysteries of nontraditional genetic processes. In Epigenetics Protocols, hands-on researchers describe state-of-the-art methods for epigenetic analysis, including recent breakthrough techniques that have great potential in the rapidly expanding field of non-Mendelian genetics. The authors provide techniques for the analysis of chromatin remodeling, such as histone acetylation and methylation. In addition, methods in newly developed and especially promising areas of epigenetics, such as telomere position effects, quantitative epigenetics, and ADP ribosylation are covered. There is also an updated analysis of techniques involving DNA methylation and its role in the modification, as well as the maintenance, of chromatin structure. Of special interest are potentially revolutionary techniques. These include methods for determining changes in native chromatin, methods of microarray analysis applied to epigenetics, and methylation-sensitive single-strand conformation techniques. The methods are suitable not only for studying fundamental biological processes, but also for investigating possible therapeutic interventions and such diseases as cancer. The protocols follow the successful Methods in Molecular BiologyTM series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and easy to use, Epigenetics Protocols offers investigators readily reproducible techniques that will further promote progress in this critically important field.


Epigenetics And Chromatin

Epigenetics and Chromatin PDF
Author: Philippe Jeanteur
Publisher: Springer Science & Business Media
Size: 41.64 MB
Format: PDF, Kindle
Category : Science
Languages : en
Pages : 266
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Epigenetics And Chromatin Book Description

by Philippe Jeanteur, Epigenetics And Chromatin Books available in PDF, EPUB, Mobi Format. Download Epigenetics And Chromatin books, Epigenetics refers to heritable patterns of gene expression which do not depend on alterations of genomic DNA sequence. This book provides a state-of-the-art account of a few selected hot spots by scientists at the edge in this extremely active field. It puts special emphasis on two main streams of research. One is the role of post-translational modifications of proteins, mostly histones, on chromatin structure and accessibility. The other one deals with parental genomic imprinting, a process which allows to express a few selected genes from only one of the parental allele while extinguishing the other.


Dna Methylation Epigenetics And Metastasis

DNA Methylation  Epigenetics and Metastasis PDF
Author: Manel Esteller
Publisher: Springer Science & Business Media
Size: 22.13 MB
Format: PDF, Docs
Category : Medical
Languages : en
Pages : 310
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Dna Methylation Epigenetics And Metastasis Book Description

by Manel Esteller, Dna Methylation Epigenetics And Metastasis Books available in PDF, EPUB, Mobi Format. Download Dna Methylation Epigenetics And Metastasis books, This book provides a broad and rich outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. It describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in the different tumor types of the human anatomy and their association with tumoral behaviour. It also provides a comprehensive insightful look at the molecular players involved in DNA methylation, histone modification and chromatin remodelling complexes causing epigenetic lesions linked to the metastasic phenotypes. Finally, it explains how epigenetic lesions associated with cancer spreading can be targeted using new and potent chemotherapy drugs. The book is a state-of-the-art reference to all scientific researchers and clinicians interested in the understanding of the biological processes leading to tumor dissemination and to those that are keen to translate this knowledge to a better management of cancer patients. Each contributor is a specialist in their epigenetic area and their joint effort has created a unique view of the DNA methylation, histone and chromatin changes that define cancer metastasis.


Cancer Epigenetics

Cancer Epigenetics PDF
Author: Trygve Tollefsbol
Publisher: CRC Press
Size: 33.92 MB
Format: PDF, ePub
Category : Science
Languages : en
Pages : 472
View: 6177

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Cancer Epigenetics Book Description

by Trygve Tollefsbol, Cancer Epigenetics Books available in PDF, EPUB, Mobi Format. Download Cancer Epigenetics books, During the past few decades, it has become increasingly apparent that heredity is not the sole determining factor in disease development, such as cancer. This landmark work covers a wide array of aspects in the relatively new area of epigenetics, ranging from its role in the basic mechanisms of tumorigenesis, to the newest epigenetic drugs being developed and used for cancer therapy. Cancer Epigenetics presents in-depth discussions of DNA methylation alterations, histone and RNA modifications, and nucleosome remodeling, which are all intimately involved in the formation of tumors. It also analyzes metabolic influences on cancer epigenetics and advances in epigenetic cancer gene therapy. Discusses the Latest Advances in the Role of Epigenetics in Tumor Initiation, Progression, and Metastasis With stand-alone chapters written by research pioneers in the field, this definitive resource covers— DNA methylation and cancer Histone modifications in cancer Emerging areas of cancer epigenetics Epigenetics in the diagnosis, prognosis, and therapy of cancer Future directions in epigenetic cancer research Bringing together different topics into a single compilation, this text is a prime resource for those with interests ranging from the basic mechanisms of tumor biology to cancer therapy. It also serves as a core textbook for advanced courses with a focus on genetic diseases, molecular biology, and/or cancer. This seminal work answers the call for a thorough and authoritative reference that covers the critical and contemporary aspects of this revolutionary field.


Epigenetics And Disease

Epigenetics and Disease PDF
Author: Susan M. Gasser
Publisher: Springer Science & Business Media
Size: 33.43 MB
Format: PDF, Docs
Category : Medical
Languages : en
Pages : 270
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Epigenetics And Disease Book Description

by Susan M. Gasser, Epigenetics And Disease Books available in PDF, EPUB, Mobi Format. Download Epigenetics And Disease books, Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders. Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, have been approved by FDA for treatment of cancers such as CTCL, MDS, and AML. This volume explores the scientific background for clinical applications of epigenetically active drugs. Included are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs, as well as new findings from stem cell research which are relevant to pharmacological applications.


Epigenetics And Human Reproduction

Epigenetics and Human Reproduction PDF
Author: Sophie Rousseaux
Publisher: Springer Science & Business Media
Size: 36.69 MB
Format: PDF
Category : Medical
Languages : en
Pages : 372
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Epigenetics And Human Reproduction Book Description

by Sophie Rousseaux, Epigenetics And Human Reproduction Books available in PDF, EPUB, Mobi Format. Download Epigenetics And Human Reproduction books, Epigenetics is a rapidly expanding field in medical and biological research which concerns heritable traits that are not attributable to changes in the DNA sequence. Epigenetic mechanisms play key roles in many biological processes, and it has become clear that their disruption can gives rise to diverse pathologies in humans. Edited by preeminent experts, Sophie Rousseaux and Saadi Khochbin, this volume in the ‘Epigenetics and Human Health’ series discusses the role of epigenetics in human reproduction


Epigenetics In Biology And Medicine

Epigenetics in Biology and Medicine PDF
Author: Manel Esteller
Publisher: CRC Press
Size: 23.27 MB
Format: PDF
Category : Science
Languages : en
Pages : 312
View: 374

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Epigenetics In Biology And Medicine Book Description

by Manel Esteller, Epigenetics In Biology And Medicine Books available in PDF, EPUB, Mobi Format. Download Epigenetics In Biology And Medicine books, Anomalous epigenetic patterns touch many areas of study including biomedical, scientific, and industrial. With perspectives from international experts, this resource offers an all-inclusive overview of epigenetics, which bridge DNA information and function by regulating gene expression without modifying the DNA sequence itself. Epigenetics, in its


Epigenetics Of Aging

Epigenetics of Aging PDF
Author: Trygve O. Tollefsbol
Publisher: Springer Science & Business Media
Size: 63.84 MB
Format: PDF, ePub
Category : Medical
Languages : en
Pages : 469
View: 4607

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Epigenetics Of Aging Book Description

by Trygve O. Tollefsbol, Epigenetics Of Aging Books available in PDF, EPUB, Mobi Format. Download Epigenetics Of Aging books, Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.


Nutrients And Epigenetics

Nutrients and Epigenetics PDF
Author: Sang-Woon Choi
Publisher: CRC Press
Size: 36.78 MB
Format: PDF, Mobi
Category : Medical
Languages : en
Pages : 258
View: 6074

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Nutrients And Epigenetics Book Description

by Sang-Woon Choi, Nutrients And Epigenetics Books available in PDF, EPUB, Mobi Format. Download Nutrients And Epigenetics books, Explores the Newly Discovered Link Between Nutrition and EpigeneticsCurrent research suggests that nutrients are more than just food components and that certain nutrients can impact the expression of genes that lead to the development of chronic diseases. With contributions from experts in both fields, Nutrients and Epigenetics examines the epigene